Chapter 9. Strategies and principles for preventing generational degeneration

Currently, we can state that the decline in the level of health, and therefore the compensatory capabilities of patients, has decreased significantly, and previously existing treatment regimens for diseases have become ineffective.Diseases began to manifest earlier, were more severe with a large number of complications and often pharmacoresistance (insensitivity) to classical drugs;At the same time, the number of patients is progressively increasing, including the number of patients with previously considered rare disorders.The ineffectiveness of existing therapeutic strategies is explained by several factors.The first and main one is described in the section devoted to a relatively healthy contingent, which also shows a decrease in the body’s resources, therefore, the resistance of such an organism to infectious load and environmental factors, emotional stress is less active and less effective.

Second: an increase in the number of pathogenic factors simultaneously affecting the body (food and biological agents).The third is multisystemic and the development of combined and often primary comorbid pathology.

The set of processes described by us as the total compensatory potential is included in the concept of sanogenesis.Sanogenesis is a complex of protective and adaptive mechanisms aimed at restoring impaired self-regulation of the body.In a pathological state, sanogenesis reactions contribute to overcoming the disorders that have arisen in the body and to recovery.The development and outcome of the disease are determined by the interaction of factors of pathogenesis and sanogenesis.At the same time, the approaches used in therapy take into account exclusively the mechanisms of disease development, that is, pathogenesis and the symptomatic picture of the consequences, and therapeutic strategies are aimed at reducing the severity of symptoms of the disease, less often at intermediate links in pathogenesis, and extremely rarely at etiological (root cause) factors.There are no attempts to influence sanogenetic mechanisms in these same approaches.

The severity of the disease, chronicity of the process and the risk of developing complications are determined not only and not so much by etiopathogenetic factors, but by a total decrease in compensatory capabilities, that is, even powerful anti-inflammatory therapy aimed at destroying the pathogen may not give a significant result and may not prevent chronicity of the disease or a dramatic outcome in a low-resource immunodeficient patient.Thus, chronic carriage of herpes viruses worsens after an intercurrent infection, that is, a common ARVI, and sometimes emotional stress or stress can contribute to a relapse.At the same time, the same strain of herpes virus in a relatively healthy organism will cause exclusively localized rashes, and in a low-resource organism it can lead to the development of severe damage to the central nervous system with a fatal outcome.Another illustrative example is the resistance of symptoms and relapsing course, despite antiviral therapy, in patients who simultaneously have chronic parasitosis or intestinal dysbiosis with severe fungal contamination.Another reason for such a course of a viral infection will be the presence of chronic emotional stress in the patient, sleep disturbances as a consequence of chronic adrenal dysfunction and a consequence of developing dysfunction of the immune system.

Chronic viral infection, in turn, leads to overstrain of the immune system and increases the load on the weakened adrenal glands.Thus, the first vicious circle is formed.

Long-term depletion of the immune system and chronic inflammatory process over time inevitably lead to erroneous auto-aggressive reactions of the immune system with the development of autoantibodies, that is, the manifestation of an autoimmune process.Therefore, understanding this concept of the formation of vicious immunometabolic circles, it is necessary to radically reconsider approaches to the diagnosis of so-called comorbid, that is, parallel existing and “seemingly” unrelated processes, towards the search for their etiopathogenetic relationships, and autoimmune damage to any organ system should be considered as an integral element of the systemic autoimmune process.

The development of a systemic autoimmune process is a natural consequence of a decrease in the activity of sanogenetic mechanisms, which can be caused either by their depletion (for example, due to prolonged exposure to a pathogenetic factor), or by the constitutionally low resource capacity of a particular organism, and often by a combination of these two factors.The compensatory capacity of sanogenetic mechanisms is primarily determined by hormonal status, which has been steadily declining over the last three generations.The decrease in hormonal status is caused by three more factors - an increasing antigenic load, mainly due to an increase in food antigens, a toxic load due to the increased use of chemicals in agricultural activities and a change in the balance of carbohydrate foods in the diet used.

In the presence of an autoimmune disease, one of the tests that determines the overload of the immune system is a food intolerance test, that is, determining the amount of immunoglobulins produced by the immune system for each food product.Each product can cause an immune reaction of varying severity.Moreover, with the accumulation of such various food stimuli, a violation of tolerance and overload of the immune system develops quite quickly, with subsequent manifestations of intolerance to a number of products.At the same time, nutritionists on TV still talk about the need to have a varied diet and introduce the maximum number of different, including exotic, foods, even for children, who have an even more reactive immune system.

Thus, with the developing dominance of consumption ideas, the total antigenic load has increased significantly and continues to grow steadily, since even the same fruit, but with or without GMOs, will be perceived by the body, and the immune system in particular, as different antigens, and crossing cultures leads to the development of cross-allergy.At the same time, the existing primitive theory that all products entering the gastrointestinal tract are completely broken down into fundamental molecules, proteins into amino acids, carbohydrates into glucose molecules, and fats into simple fatty acids, and only these elementary molecules are absorbed and used, and the rest is excreted from the body, has long been refuted by clinical observations and laboratory tests.Unfortunately, in the body everything is much more complicated.In addition to immunological reactions to different foods, even different sources of fatty acids, the body's response will vary.Thus, it is known that vegetable oils and animal fats, despite their chemical similarity and molecular composition, will have different effects on intestinal permeability and are absorbed differently.As mentioned earlier, the permeability of histological barriers, including the intestinal barrier, significantly influences the stability of immune responses.The steadily increasing total antigenic load underlies the population decline in immunity and the increase in the number of autoimmune diseases.In addition, in recent years in our clinic we have noted an increase in the number and severity of post-vaccination complications in children and adults.The risk of such complications increases with the use of polyvalent vaccines, however, even the use of single-vaccination drugs does not reduce the risk of developing autoimmune reactions to zero.The medical literature describes cases of manifestation of type 1 diabetes mellitus in adult patients after vaccination against coronavirus infection.We monitor both patients with manifestations and patients with relapses of rheumatoid arthritis, AIT and IBD after preventive vaccination.The severity of autoimmune complications in these patients is comparable to the severity of those after a coronavirus infection.Understanding the essence of these processes makes it necessary to formulate extensive pre-vaccination screening, including tests for the state and reactivity of the immune system.So far, post-vaccination complications occupy a seemingly insignificant share in the total number, but the trend leaves no doubt that over time their number will grow and in the foreseeable future the problem will become so obvious that it will become impossible to ignore it.

The modern agricultural industry, to a much greater extent than before, uses innovative opportunities to maintain and increase yields, as well as control pests.This undoubted progress inevitably leads to traces of pesticides, herbicides and other chemical agents that have mutagenic, cytotoxic and mitotoxic effects entering food products.Even with preserved detoxification function of the liver, the described chemical agents are difficult to remove from the body, and for already intoxicated low-resource organisms, this additional load becomes one of the significant impetus for the development of mitochondrial dysfunction, which, in turn, affects all body systems, in particular the immune and hormonal ones.Since the 50s of the 20th century, at the suggestion of the Association of American Cardiologists, recommendations for a total reduction in the percentage of fat in a normal diet were introduced into clinical practice.Calorie compensation in recommended diets was carried out at the expense of so-called long carbohydrates, as a result of which in a modern typical diet the share of carbohydrates consumed has reached 80%.Additional recommendations on the need for split five or even six meals a day not only did not reduce the incidence and prevalence of cardiovascular diseases and atherosclerosis in particular, but, on the contrary, led to an intensive increase in the frequency of metabolic syndrome.Metabolic syndrome is a combination of metabolic disorders in the form of obesity and increased blood glucose levels.Patients with metabolic syndrome develop secondary hormonal dysfunction, which, in turn, aggravates the course and severity of metabolic syndrome.

Patients with the described complex of comorbid conditions that develop on a single pathogenetic basis inevitably have a reduced reproductive potential, men experience an early decrease in potency and impaired spermatogenesis, and women with an initially full follicular reserve, that is, a normal number of future eggs, against the background of hormonal imbalances, suffer from menstrual cycle disorders, anovulatory cycles (that is, cycles that are not accompanied by maturation and formationa complete egg ready for fertilization), polycystic ovary syndrome and endometriosis with subsequent difficulty in achieving pregnancy, an increased risk of gestational diabetes and its consequences for the developing fetus, etc.

Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder, naturally concomitant and pathogenetically associated with metabolic syndrome and insulin resistance, in the modern world it occurs in 6-20% of women of reproductive age and occupies a significant place in the causes of infertility in young women.

According to current statistics, up to 10% of pregnant women experience the development of gestational diabetes mellitus, and excess body weight (BMI) remains a key risk factor for its development.

The causes of infertility and pathology in pregnant women over the past decades have significantly shifted from the tubal factor, that is, mechanical difficulty in the passage of the egg into the uterine cavity, to the total collapse of the entire sequence of hormonal transformations that predispose to the normal physiological course of gestation.

Hormonal support, which was previously used in the presence of a threat of miscarriage, bleeding or increased uterine tone, has become almost a universal preventive practice in modern obstetrics and gynecology and has ceased to be a factor in the “unphysiological” nature of pregnancy.Nevertheless, pregnancies that occur and are prolonged due to, in fact, replacement therapy in patients with chronic inflammatory processes and autoimmune diseases are a significant risk factor for the birth of low-resource, immunocompromised offspring.

A child’s low-resource organism develops against the background of a deficiency of all factors necessary for full growth and development.In conditions of deficiency, the body develops with the need to prioritize areas.Thus, until the basic needs of the body aimed at survival are realized, the development of the most complex functions, including psycho-speech development and opportunities for socialization, will not begin.Until the child masters and consolidates motor skills, the development of higher cortical functions will be significantly slowed down and difficult, and stimulation of the development of these areas without compensating for the deficient ones will inevitably lead to negative side effects and repeated regressions in development.

The treatment tactics for the recovery of an adult should also be consistent, with similar principles of prioritization.

Therapeutic interventions aimed at stopping the formed negative trend are based on overcoming key predisposing factors - a return to an elimination style of nutrition, reducing the carbohydrate load, reducing the antigenic load with the consistent restoration of sanogenetic mechanisms and compensatory resources of the body.

The general principle for solving those complex problems that have already been formulated is the restoration of sanogenetic resources by increasing compensatory potential, primarily by controlling and replenishing hormonal deficiencies.The second task is to separate the links in the chain of pathogenesis, that is, to break the formed vicious circles, which will stop personal degeneration in each family separately and each individual of this family in particular.And the adoption of systemic comprehensive measures aimed at changing the consumption structure, nutrition system, vaccination schedule and pre-vaccination screening system, as well as a possible revision of the classification, diagnosis, treatment and prevention of many diseases will require time, effort and courage - both from specialists and from government officials.