Chapter 3. Pathogenesis of various diseases

Of the many causes of disease, two main ones can be distinguished.The first is injuries.Anyone at any age can break an arm or leg.The initial status of a person also plays a huge role in this case, since injuries and fractures in older people require long-term rehabilitation and heal extremely poorly.However, these events are random and, within the framework of generational degeneration, do not make much sense.

The second reason why the body as a whole and individual organs in particular is damaged is inflammation.The inflammatory process is usually divided into septic and aseptic.

An example of an aseptic process is inflammation in tissues in which blood circulation has been disrupted and metabolic products accumulate.Septic inflammation is caused by a known external agent that can enter the body in various ways.This inflammation can be local, for example itching in the perineum with sexually transmitted diseases, or a runny nose with ARVI, or a local skin reaction to an insect bite.

Local inflammation is determined by characteristic signs: redness, swelling, fever, pain and dysfunction of the damaged organ.The immune system reacts to local damage, special cells of the immune system migrate there, which locally neutralize the source of damage, then recovery processes are launched, and local inflammation subsides.

In the case of a local reaction of the mucous membrane of the oropharynx and nasopharynx, the production of a special secretion and mucus is activated, which has a disinfecting and detoxifying effect.Using the example of local inflammation, three periods can be distinguished: activation of the acute phase and fight against antigen, detoxification (opening of an abscess, self-cleansing of the wound, diarrhea syndrome and vomiting in case of poisoning, lacrimation in case of hay fever, etc.) and the third stage - regeneration (wound healing and restoration of function).

The cause of severe diseases is often a systemic inflammatory process, in which pathological changes are widespread and cascading.A secondary systemic inflammatory process occurs if it is not possible to eliminate the antigen at the level of the local inflammatory reaction and pathological changes begin to spread (abscess turns into sepsis, appendicitis into peritonitis, tonsillitis or acute respiratory viral infection into bronchopneumonia), that is, from a local process, spreading, it turns into a systemic and - often - life-threatening process.

The spread of the infectious process occurs when natural compensatory protective mechanisms are “broken”, both in the mode of mechanical and immunological damage.Subsequently, the compensatory potential of this damaged organism becomes even lower, and its susceptibility to subsequent immune stress increases sharply.That is, in the presence of a rheumatic disease, such as arthritis, an exacerbation and the appearance of systemic clinical signs can be caused by any mild cold that another person will suffer on their feet and not even take sick leave.

Similar patterns are observed in resistance to emotional and physical stress in patients with panic attacks and asthenic syndrome.Thus, the key importance is the relationship between the sum of all provoking factors and the level of resource that the biological organism has at the time of stress.

During emotional stress, infectious processes are more severe and are often accompanied by complications.The first symptoms of serious diseases, such as type 1 diabetes mellitus, autoimmune thyroiditis, multiple sclerosis, rheumatoid arthritis, often appear after a psycho-emotional shock, which is superimposed on a common ARVI.This sequence often leads specialists to the conclusion about the psychosomatic genesis of the described diseases, inclining all therapeutic tactics towards psychotherapeutic work.

However, the true significance of psycho-emotional stress in the pathogenesis of the described diseases lies in their effect on hormonal status and then, indirectly, on the function of the immune system.Another combination of factors leading to the development of an autoimmune process is repeated inflammatory episodes of moderate severity that develop over a limited period of time.Of similar importance is vaccination carried out in a short period after suffering from inflammation, or suffering from a disease after vaccination, as well as the excess polyvaccine load itself.

The third option for the impetus for the development of an autoimmune disease is a chronic load of various antigens, which, as a rule, occurs against the background of an initially immunodeficient status.

Thus, the key issue in any inflammatory process is the ratio of the sum of all antigens that are in the body, that is, the sum of all both pathogenic and conditionally pathogenic factors and the compensatory capabilities of the body.

For the comprehensive management of the described serious diseases, simultaneous work in two directions is required - systemic and complex antigenic unloading with subsequent detoxification and the regeneration stage, and restorative work with the compensatory status of the person.

Currently, in classical medicine, when assessing the pathogenicity of bacteria, fungi and viruses, four groups of pathogenicity are distinguished, which depend on the severity of the clinical picture they cause and the risk of occurrence.Most of the inhabitants of our body belong to the so-called opportunistic organisms, that is, Staphylococcus aureus, E. coli, Candida, and the herpes virus can be detected in every human body using laboratory diagnostics, but their presence does not cause any clinical picture.However, their activation is possible in case of additional stress on the immune system.For example, a person, falling ill with a common cold, discovers an exacerbation of a chronic herpetic infection, which can go away on its own after the body recovers from the cold.

Other triggers for exacerbation of the same herpes can be severe emotional stress or excessive physical activity.

That is, conditionally pathogenic organisms alone do not have any significant effect on the human body.The clinical picture of the disease can appear either in the case of an excessive increase in the number of pathogens of one type in the body, or an increase in the number of types of microorganisms that in themselves are safe, but in an excessive set overload the immune system.This condition can be designated by the term “total antigenic load.”The critical value of this total load is individual.In a low-resource organism with insufficient compensatory immune reserve, even a small total load can lead to the development of a pronounced clinical picture with various complications and transition to an autoimmune disease.For a highly resourceful organism, a high antigenic load will not be critical as long as it remains highly resourceful.The state of immunity and resource is determined by factors of hormonal regulation and the state of cellular metabolism.That is, a deficiency of hormones, minerals, vitamins, amino acids will reduce the effectiveness and severity of the immune response, and therefore make the body more susceptible to antigens.

The compensatory capabilities of a biological organism are not an ephemeral set of certain resources, but a calculable and adjustable status, which can be designated as “total compensatory potential,” which includes an assessment of the effectiveness of the immune and detoxification systems, hormonal regulation, mitochondrial status and membrane integrity, generally based on correct metabolism.

The success of anti-inflammatory therapy will depend on the state of this balance—the total antigenic load and the total compensatory potential.

This became especially noticeable during the coronavirus pandemic, when people with a history of metabolic diseases (metabolic syndrome, obesity, diabetes mellitus) or chronic inflammatory diseases suffered COVID-19 with a large number of complications and a high risk of decompensation of the existing pathology, as well as a significantly higher risk of death.This was obvious in the case of elderly patients with low hormonal status and a set of concomitant pathologies, but also concerned young patients with the presence of concomitant metabolic and immunological diseases.Another severe consequence of the disease in low-resource patients was the development of post-Covid syndrome with the formation of persistent asthenovegetative symptoms, emotional disorders and the onset of autoimmune diseases.

People with a high compensatory reserve endured even a severe form of coronavirus infection without significant complications.

Similar patterns can be traced at the stage of recovery after any illness.Young people recover faster from traumatic injuries and have a milder course and lower risk of complications from infectious diseases.Similar diseases in the older age group will be more severe, with a longer recovery.In old age, even minor injuries or stress can lead to debilitation or the development of serious conditions such as dementia.

It would be logical to develop a strategy that would take into account the described patterns, that is, that, in addition to symptomatic and pathogenetic therapy (antiviral for viral infections, hormone replacement therapy for diabetes, etc.), it is necessary to pay attention to monitoring the entire spectrum of the total load and at the same time increase the total compensatory potential through adequate correction of metabolic processes and the hormonal levels that regulate them.

In 2018, we formulated and announced a three-stage concept for the treatment of autoimmune diseases and recovery of the body.

The first stage is the stage of antigen unloading.

The second stage is the detoxification stage.

And the third stage is the regeneration stage.

In the process of evolution of the concept, the tools of the first stage were detailed and expanded, the efficiency was increased and hardware methods were included in the second stage, a unique methodology of hardware and biological methods for enhancing the regenerative and restorative processes of the third stage was developed.In recent years, it has become clear that the hormonal status of patients plays a critical role in the success of treatment of chronic infectious and autoimmune diseases; maintaining it in optimal condition is crucial at each stage.The experience gained in the use of hematopoietic stem cells from umbilical cord blood has become a new horizon in correcting the immune status and stimulating regenerative processes.To date, we are the only ones who have successful experience in using these technologies to treat serious diseases.In further chapters, I will reveal in detail the theoretical mechanisms and practical aspects of the application of the described concept in the treatment of various diseases and, most importantly, for the improvement of those people who are at risk for developing serious diseases.As mentioned in previous chapters, this problem will affect every family within the next one or two generations.