Chapter 4. Antigenic unloading
Our body daily encounters a series of biological and non-biological objects that are foreign to us.For our body, everything that is not itself is foreign.And everything alien, not related to man, is a threat, a danger to him.And, just like we, even when we are among people, and even more so, if we find ourselves, for example, in the jungle, we will be tense because we do not feel safe, so the body at the microbiological level is always in a state of background protection, background tension.He cannot relax, because there are viruses, parasites, bacteria, fungi around, and all of this is waiting for the right time to make the body their prey, their place of life, begin to parasitize on it, take away nutrients, energy, or use it as a container for moving their pathological genes in space.This depends on the life cycle of the pathogens.Animals that can be carriers of diseases but not get sick are also used according to the same principle.And a person can be a carrier without having a clinical picture of the disease or complaints.
Other foreign objects, for example food, until it is broken down, are the product of gene pools that are foreign to us, but plants have their own genetics, and animals have their own genetics, which is foreign to us, which means that encountering it requires straining the immune system, which must recognize these and other biological objects.
The more viruses, fungi, parasites and other pathogens around us, the more the body has to strain.The more we consume different foods, the more our body, our immune system has to make efforts.Let me decipher: by reacting to each sequence of foreign genes and detecting it according to the “friend or foe” principle, the immune system spends its resource, which is quite large, but not unlimited.
If the resources of the immune system are overloaded or reduced, it either stops responding to other stimuli or begins to react to them excessively, hyperreactively.Therefore, dysfunction of the immune system will be characterized by either a decrease in efficiency up to a state of immunodeficiency, or the development of hyperreactivity up to autoimmune aggression.And often these processes are combined and occur in one body at the same time, then the inflammation becomes both infectious and autoimmune at the same time.
Immunity overload can occur for various reasons, but most often it is associated with antigenic load.The higher the sum of all foreign agents encountered by the immune system, the harder it is to work.The total antigenic load can occur in different combinations.
It may be a combination of different antigens, each of which is recognized in small quantities by itself.And if we consider each group separately, then, for example, a small viral load is not critical, a small fungal load is also not dangerous, and mild manifestations of dysbiosis are not terrible, and the consumption of various products also does not cause any allergic reaction and does not trigger any super-pathological manifestations.However, with simultaneous exposure to the body, a systemic inflammatory reaction will manifest itself - the result of exposure to the total load and overload of the immune system as a whole.
As mentioned above, the critical load level is individual and can be achieved in different ways: with excessive exposure to a single pathogen, simultaneous exposure to several groups of pathogens, or with a decrease in the compensatory potential of an individual.
The main question is: how has the critical level of immunity been overcome?Almost the entire treatment and recovery strategy depends on the answer to it.
And with this question great difficulties arise.Why?Classical medicine perceives only the exclusively monofactorial genesis of the inflammatory process, ignoring the presence of a background antigenic load.
That is, when a person is diagnosed with meningitis based on the clinical picture, they take tests from him and see who the causative agent is - meningococcus, herpes or some other pathogen.And, having isolated this pathogen from the cerebrospinal fluid and/or blood, they begin active treatment with either antibacterial agents or antiviral drugs.The same applies to any inflammatory process: a smear is taken, the discharge is cultured, microbes are sown, and then their sensitivity to antibacterial drugs is determined.This is how classical medicine works.And before, even twenty years ago, this approach was indeed sufficient in most cases.
But in our time, due to the increase in hormonal disorders, mitochondrial and immune dysfunction, the role of monofactorial inflammatory processes has significantly decreased.The branch of medicine that takes a systematic approach to treating low-resource patients is called mitochondrial medicine.
Representatives of this direction are engaged in the study of multifactorial etiopathogenesis of diseases.
When we talk about total brain damage, each factor individually from the standpoint of classical and evidence-based medicine will be insignificant.Why?Because, for example, in a child diagnosed with chronic subacute encephalitis, concentrations of herpes viruses and cytomegalovirus may be detected.But the titers of the detected viruses are not high enough, and classical doctors in this case will say that there are a lot of people in whom the herpes virus and cytomegalovirus are detected in much larger quantities without clinical manifestations.This means that our hypothesis that in this particular child these particular viruses are the cause of his problems is not valid, and there is no need to treat him with antiviral drugs.An excellent logical maxim, but, unfortunately, it does not cure encephalitis.Our task is to cure the patient.In this case, a patient whose immune status is so deficient that the detected viral load titer is sufficient for the development of a severe neurological condition.
Even more interesting things happen with the inflammatory processes of other organs and systems.The etiology of many diseases still remains unknown, and hypotheses about the role of viruses in damage to joints, muscles, pancreas and thyroid glands, and the nervous system at any age have been consistently rejected.Often, antiviral therapy improved the condition of patients, but laboratory pathological studies of the affected organ did not confirm the presence of the virus in it.Over time, the diagnostic search was turned towards the search for genetic predispositions to inflammatory and autoimmune diseases.In our opinion, a diagnostic search in the area of genetic abnormalities has no practical meaning, does not change therapeutic tactics and cannot change the course of the disease.And the presence of a verdict on the verification of a genetic abnormality stops the diagnostic search and often the entire treatment process.
Another feature of the course of modern diseases is the nonspecificity and vagueness of clinical manifestations, that is, the same set of symptoms characteristic, for example, of encephalitis, colitis or arthritis, can be caused by completely different pathogens, or more often by a combination of them.This is of particular importance in the context of autoimmune diseases, when it is simply impossible to identify an obvious trigger from the great variety of microorganisms in the body, but this does not mean that it does not exist.
The bacterial load emanating from the intestine can lead to systemic intoxication and toxicosis and subsequently cause damage to the central nervous system, which may respond in different ways.In one patient, the level of intoxication will lead to chronic fatigue syndrome, while in another the same level can cause seizures.In this case, no pathogens will be detected in the brain or cerebrospinal fluid, since the main pathological effect is determined by toxins and waste products of bacteria.
For example, clostridia will realize their effect precisely through toxins.In the classic version, clostridial infection is a pure disorder of the gastrointestinal tract, which will manifest itself as constipation and abdominal pain, that is, intestinal symptoms.
According to the classical approach, for clostridial exposure to damage nerve tissue, the infection must be severe and manifest itself as a clinical picture of tetanus.But most of the patients we meet, of course, do not have tetanus.However, the level of intoxication is high enough for neurological symptoms to develop.
But when we talk with classical doctors, none of them will believe that clostridial contamination of the intestine without obvious intestinal symptoms can cause serious neurological diseases, including the development of dementia, multiple sclerosis or convulsive syndrome.
The same can be said about autoimmune thyroiditis.This disease can be triggered by various pathogens.Until now, from the point of view of classical medicine, the etiology of neither multiple sclerosis, nor autoimmune thyroiditis, nor rheumatoid arthritis, nor psoriasis is unknown.Is there a reason?
We understand that every disease has a cause and there is a starting point where the disease begins.And if we have not found this reason, this does not mean that it does not exist.Our efforts should be aimed at a comprehensive effect in order to heal the body.
The development of traditional medicine is significantly hampered by a one-sided view and monocomponent, or even symptomatic, therapy, which only temporarily alleviates a person’s condition, while the disease continues to progress.
So, the key point in the development of the disease is overcoming the reserve threshold of the immune system, that is, just the individual exceeding that same threshold of autoimmune load.And it is mostly polyetiological in nature, while the proportions of those pathogens, both external, for example food, and internal - fungi, parasites, bacteria and viruses, can be individual.
For some, nutritional factors come first in the development of autoimmune diseases, namely overloading the diet.Diet plays a huge role in the development of autoimmune diseases; there are many elimination strategies (excluding certain foods from the diet).Often these strategies exist and are used separately from each other.These are options for a gluten-free, casein-free diet, exclusion from the diet of foods to which there is food intolerance, options for mono-diet, or complete exclusion of foods, that is, hunger strikes of varying durations.
All of these strategies have been successful to varying degrees in the treatment of chronic inflammatory diseases, including autoimmune diseases, and this applies not only to intestinal diseases and allergies, but also to systemic diseases such as multiple sclerosis, rheumatoid arthritis, AIT or autism.The experience gained formed the basis of a new direction in dietetics - elimination dietetics.Unlike nutritional nutrition, which has dominated thinking about healthy eating for the past decades, elimination dietetics has only recently begun to attract attention.
Complementary dietetics analyzed food products from the standpoint of detecting useful substances, microelements, vitamins, and amino acids in them, while it was believed that the more varied the diet, the more saturated the body will be with useful substances.This idea was picked up by the food industry, which provided a year-round selection of various, including exotic fruits, juices, and canned foods.It was argued that all these products are good for health, sometimes it sounded directive: “milk contains calcium, a child will not grow without it,” “millet contains B vitamins, our body needs them,” “canned yogurt contains beneficial bifidobacteria, without them the intestines will not work,” “the intestines need fiber in large quantities,” “fruits are a source of vitamin C, without it the immune system will not work.”All this should be considered solely as advertising slogans.
At the same time, packaged dietetics does not take into account the potential harm of products, and many of them contain potential food allergens - lectins, gluten, casein;These products may also contain chemicals, nitrites, nitrates, glyphosate, etc. All this directly or indirectly negatively affects the condition of the body, changing the intestinal microbiota, the permeability of the intestinal wall, the functioning of mitochondrial enzymatic systems, overloading the detoxification mechanisms of the liver, the secretion of enzymes in the gastrointestinal tract and ultimately disabling the immune system both locally and systemically.All these problems can be avoided by using the principles of elimination dietetics as a basis.
Elimination of food allergens and substances that directly or indirectly irritate the immune system is the main stage of antigenic unloading.Often already at this stage the patient begins to feel relief and improvement in overall well-being.It would seem that these principles are simple, but they unload the immune system from food triggers and local and general immunity, which allows you to switch the freed one to fight true pathogens.It is not surprising that people who adhere to these nutritional principles are less likely to get colds, have fewer problems with the gastrointestinal tract, skin, nasopharyngeal diseases in children, including enlarged adenoids, and behavior in children with ADHD and adults with asthenovegetative syndrome stabilizes.
The basic element of elimination is the exclusion of gluten, and therefore all flour products.Of course, we have more than once heard objections that “bread is king”, “our grandfathers ate bread, and they didn’t have any problems,” and doctors put forward arguments that, according to genetic tests, celiac disease was not detected and there are not enough antibodies to gluten, which means there is no reason to limit the consumption of gluten-containing products.However, gluten is perhaps the most well-known and reactive factor in the development of the immune system response, influencing both directly and indirectly.Direct action is the result of hypersensitivity to gluten, which causes inflammation and damage to intestinal cells.Indirect effects are associated with the formation of dietary opioid peptides.
There are several variants of the pathological response to gluten, which can be divided into three groups: autoimmune gluten intolerance (celiac disease, dermatitis herpetiformis, gluten ataxia), allergic gliadin intolerance due to atopic mechanisms (food, respiratory, occupational allergies and urticaria), non-autoimmune non-allergic gluten intolerance.Of course, the most severe type of gluten-associated pathologies are autoimmune intolerances, which can be either the result of a congenital abnormality or acquired.
Gliadin induces a number of mechanisms that trigger an immune response, the key of which is the aggression of cytotoxic cells that damage enterocytes, and the secondary formation of autoantibodies that support a chronic inflammatory response.As a result of this double damaging action, the intestinal wall is constantly injured and atrophied, due to which it cannot perform its functions.In this case, in addition to intestinal pain, a person falls into a severe deficiency state called malabsorption, due to malabsorption and profuse diarrhea.Intoxication syndrome leads to a deterioration in the general condition, and the systemic autoimmune component leads to damage to organs and systems, including the central nervous system.The allergic reaction is mediated through the production of immunoglobulin E and the activation of mast cells, thereby triggering a hypersensitivity reaction.A low-resource organism often has a tendency to hyperergic reactions even with minimal provocation, while gluten is a strong allergen that can trigger a severe systemic reaction.The described effects are aggravated by indirect effects determined by the synthesis of opioid peptides as a result of incomplete breakdown of gluten and some other food peptides (for example, casein).Exorphins from gluten (gluteomorphin, exorphin A, B C) and casein (beta-casomorphins) have a proven effect on the central nervous system, changing behavior, and are persistently addictive.
Of course, not everyone who eats bread, even in large quantities, develops inflammatory and autoimmune diseases.However, in a low-resource organism in a state of total antigenic load, gluten in some cases leads to exacerbation of chronic diseases and maintains a constant level of inflammation.The same goes for casein.Gluten and casein become the “pillars” of chronic systemic inflammation in general and the inflammatory process in the intestines in particular.
Parasitosis
A low-resource organism is characterized by a constant course of an immunodeficiency state, not so deep that it would be fatal, but more than sufficient for the growth of those organisms, micro- and not very, that cannot exist in an immunologically preserved organism.In modern humans, parasitosis is a common and no longer surprising phenomenon.
Parasitology is one of the significant branches of classical medicine, but in the traditional approach it is adjacent to the study of tropical diseases and considers parasitosis as a rare condition in the practice of a clinician.
Classical medicine offers a classification of parasites according to the place of their parasitism: exo- (lices, ticks, fleas) and endoparasites, which include protozoa (amoeba, giardia) and worms, tape and round.Most parasitologists believe that the only real location and location of parasites is the intestines, and the only job they perform is to actively reproduce and release eggs.In their opinion, it is impossible not to detect parasites if you look at our secretions, whether there are eggs there or not.Life is not like that.
For a long time, due attention was not paid to parasitosis, in contrast, by the way, to veterinary medicine, in which parasitosis is the first thing to be ruled out when an animal is unwell.There are two reasons for this: passion for excessive laboratory tests and ignorance of the clinical picture.The clinical hypothesis that parasitosis may be the cause of some illness is rejected because tests do not confirm this, but practice has shown that the absence of a positive laboratory test does not mean the absence of the disease.And this only leaves the question of the quality of diagnostics, the need to expand it or search for new methods.
The symptoms caused by parasites are extremely varied and nonspecific.The main ones: asthenic syndrome, weakness, allergic reactions, decreased iron levels, often the development of convulsive syndrome, abdominal pain, the development of clinical gastritis, clinical colitis.Therefore, every specialist who does not know what parasitosis is, but deals with some kind of organ system, can find the problem and treat it: the gastrointestinal tract - with gastroenterological drugs, convulsive syndrome - with anticonvulsants, skin manifestations - with various ointments or antihistamines, asthenic syndrome will be tried to be corrected with the help of stimulants or psychotherapy.
The diversity of parasites is enormous, but the symptoms of their carriage in most cases are stereotypical and nonspecific.With the possible exception of malaria, which is characterized by a significant change in body temperature.There is a key and very important point that must be voiced - many parasites are characterized by cyclicity.And if a person has any cyclical problems and they are not directly related to the hormonal cycle, then their cause is parasitosis.By cyclicality we mean the regular repetition of certain symptoms, for example, the occurrence of convulsive attacks exactly once every two weeks (or once a week, month).
Sometimes these cycles consist of several days, for example, 3 days - exacerbation, 2 weeks - break, etc. The clinical content of these cycles can be different, wave-like skin manifestations, episodes of insomnia and changes in background mood, night awakenings, hysterics and fears, low-grade fever or fever without other catarrhal phenomena (cough, rhinitis, etc.).Often these episodes occur in accordance with the lunar cycle, coinciding with the new or full moon.
In our clinical practice, we use our own checklist of symptoms that explain and accompany parasitosis.Clinical signs can be divided into two large groups: somatic signs, often masked as other diseases, manifested externally in the form of skin manifestations, allergies and bronchospasms, obstruction and cough, especially at night, abdominal pain and non-systemic stool disorders in the form of diarrhea and constipation.
The psychoneurological group of symptoms includes vegetative manifestations: sweating when falling asleep or during sleep (local - mainly in the head area (“wet pillow”), general, which forces you to change clothes repeatedly at night, and in the case of a child, change sheets that are so wet that it is not always clear whether it is sweating or loss of urine).Sweating does not have to be very pronounced - we must attach importance to even slight sweating.Sleep talk, bruxism, shuddering when falling asleep and during sleep, nocturnal enuresis, sleepwalking, night terrors, restless night sleep with frequent turning over in bed - all these symptoms were considered by neurologists for many years as separate syndromes associated with emotional overexcitation, and by some specialists were perceived as equivalent to epileptic seizures.In fact, all of the above symptoms are the result and nonspecific manifestation of intoxication syndrome and irritation of the nervous system.
So, when at my seminars and lectures I say that antiparasitic therapy allows in some cases to get rid of anticonvulsants, classical doctors look at me with distrust and misunderstanding, although the patients who were treated by us got rid of seizures.
There is also an opinion that parasites are our natural partners who “train” our immunity, and getting rid of parasites will lead to worsening immunodeficiency.I do not entirely agree with this idea, since we see a subclinical protracted course of parasitoses that tend to progress over time, remaining undiagnosed, even according to subtle laboratory tests that reflect the tension of the general immune system.
The maximum that can often be detected is an incidentally detected and insignificant increase in eosinophils.And eosinophilia is precisely the reaction of the immune system to the presence of parasites.We see little pronounced and bright eosinophilia, but we often see an increase in the protein contained in eosinophils - eosinophil cationic protein (ECP) - the result of cell destruction.
ECP often increases along with the immunoglobulin E level, which is responsible for the hypersensitivity of the immune system and in the classical approach is perceived as an indicator of the presence of allergies.However, we see in patients with parasitosis significant overestimations of these two indicators and their normalization after antiparasitic therapy, which is the best confirmation of the correctness of our clinical hypotheses.
It happened that motivated parents, wanting to identify the parasites that had fallen out of the child, took them to the laboratory in order to clarify the class and type and select specific treatment.However, during all this time we did not receive a single intelligible answer, and the brought worms (despite the fact that there was no doubt about their animal origin based on video recordings and photographs) were described as dietary fiber.
Parasitosis itself, its type and characteristics of its course are not the most significant things; we consider parasitosis as a clinically clear consequence of an immunodeficiency state.
Normally, parasites do not stay in the body.The body is a powerful system with many layers of immune defense.They start with saliva.Next comes acidic gastric juice.Next is bile.Next are the enzymes of the duodenum, as well as the mucus that lines the intestines, and this mucin contains a large amount of immunoglobulins, which provide a local immune response.That is, the body disinfects itself, and the immune cells located in the mucus disinfect everything that is foreign to us or that poses a potential threat.If a person has manifestations of mitochondrial immunodeficiency associated with this hormonal deficiency, with a decrease in the secretion of both gastric juice and mucin, as a result of nutrition, bile flow is impaired and little bile is synthesized, little is released, which is why it does not participate in the process of intestinal disinfection, then this creates an environment for the retention and proliferation of pathogens that have entered the body.
If all protective systems function well, then even a piece of food picked up from the floor or a hug with a yard dog that has just crawled out of a street trash heap will not lead to the development of parasitosis, because the immune system will repel the attack and destroy the parasite eggs that have entered the body.
But if the immune system does not work, its barrier functions are impaired, then the body becomes their place of residence.And even with perfect hygiene, sterilization of pacifiers and toys, ironing the sheets on both sides with a hot iron, the accidental entry into the body of a minimum amount of pathogens leads to them growing to such an extent that they will be comfortable.When parasites appear in the body against the background of immunodeficiency, they are not left alone - very soon all the components of the total load are added: viruses, fungi, bacteria.And the lower the immune status, the faster the antigenic load increases.
In this case, it does not matter which pathogen was “first.”The clinical picture of the total load will be determined by those pathogens that are currently multiplying most actively.In this case, symptomatic treatment will have a temporary effect, since in general the immune system remains weakened and, left without support, safely allows pathogens to grow again.Therefore, oddly enough, in case of a chronic viral or fungal infection, one should consider the possibility of relieving the immune system through an antiparasitic program; it is possible that it was the parasites that caused the overall overload of the immune system.
Also, a parasitic background can be the cause of concomitant bacterial infections and dysbiosis, as well as, in general, a background for an immunodeficiency state in weakened adults and frequently ill children.
There are a lot of antiparasitic programs.They include pharmaceutical anthelmintic drugs and herbal antiparasitic preparations, which include cloves, tansy, wormwood and other plants.In some cases, short courses of classical drugs are sufficient, but often we need multi-stage antiparasitic therapy with parallel maintenance of detoxification systems, including in inpatient settings.We consider the successful outcome of treatment to be primarily the dynamics of the clinical picture, which is confirmed by laboratory, most often nonspecific, as described earlier, studies.
During antiparasitic programs that remove parasites from the body, the level of intoxication in the body increases.Dead, decaying parasites are themselves toxic to the body.Many biological objects release poison before escaping.The same thing happens with parasites who have left their comfort zone.They can produce mucus or a protective film that is toxic to the body.Therefore, it is necessary to support the liver, prescribe sorbents and ensure active intestinal drainage.
Why do we say so confidently that parasites are an indicator of immunodeficiency?For many of our patients, we prescribe combined human immunoglobulin (CHI), which is taken orally, for support.This is part of the intestinal support scheme, and the intestine, as we will discuss later, is a fairly significant organ that provides local immunity.80% of the lymph nodes are located in the abdominal cavity and filter what comes from the intestines.The intestines are also home to pathogens, which we feed.
In our practice, there was a case when a patient took combined immunoglobulin not for the month as prescribed, but longer.Nothing critical happened, but after two months he came and said that he felt much better than a month ago, but after a month and a half of taking it, “worms began to fall out of him.”This was a surprise for us, but we found an absolutely clear explanation - the increased local immunity due to immunoglobulins increased the local capabilities of this intestine, and the inflammation reoriented the local intestinal immune system towards the parasites remaining there.They left the body, and the patient felt much better.We did not prescribe him CIP for antiparasitic purposes.At that moment, we did not put anti-parasitic unloading in the first place in our program, it was absolutely basic intestinal support, but it gave such results.We took this into account, and now we pay increased attention to local immunity in the intestines, and the courses of immunoglobulins that we prescribe to immunodeficient patients are many times higher than the previously used doses.
Now the role of parasitosis in the clinic of autoimmune diseases, neurological, rheumatological, has grown sharply.This is precisely a consequence of the progressive increase in mitochondrial immunodeficiency, and therefore another confirmation of mitochondrial degeneration, generational degeneration.
Lyme disease
In recent years, the diagnosis of borreliosis has begun to appear in doctors’ reports much more often.In today's world, many are afraid that any mosquito or tick bite can lead to the development of Lyme disease.For many, this has almost become a phobia.
The fact that “urban” mosquitoes spread Borrelia is not a new biological event, but a change in a person’s immune status is occurring, and a significant one.The increase in the incidence of borreliosis occurs according to the same scenario as the increase in parasitosis - due to the progression of mitochondrial immunodeficiency.That is, weakened organisms react poorly to Borrelia even in small quantities.
Therefore, before, no matter who bit a person, the local reaction immediately destroyed all pathogens that entered the body, without giving them a chance to multiply.What do we see in children now?They scratch these bites, they leave not just red spots, but bruises that take a very long time to disappear.The so-called hyperergic reaction to insect bites, which occurs in “loose mitochondria.”Such reactions are one of the symptoms of loose membranes, including eosinophilic ones, which means an excessive histamine reaction and reduced basic immunity.But what a bite is is injected saliva, a foreign protein, to which the body must react quickly and at the level of the site of its introduction.But instead of localizing inflammation and quickly destroying its pathogens, the body allows a systemic process to develop and foreign proteins to enter the systemic bloodstream.
A trained, strong immune system does not notice these bites at all, quickly “cleanses up” and forgets.And in today's children these bites are of an over-irritable nature.The response to the Mantoux reaction in children becomes the same hyperergic response of the immune system.If previously, based on the volume of the local reaction, one could suspect a specific response of the body that came into contact with mycoplasma tuberculosis, now all reactions are nonspecific, gross and in no way related to tuberculosis, which in extreme situations lead to a systemic response as well.
Previously, a lower incidence of borreliosis was associated with a high level of mitochondrial immunity, that is, high reactivity and adequate immune response to the pathogen entering the body.Now the progress of borreliosis is due precisely to the fact that the reactivity of the immune system has decreased.The blurred, nonspecific clinical picture of modern borreliosis, along with its systemic nature and extremely frequent involvement of the nervous system in the inflammatory process, are typical characteristics of borreliosis of our time.
Mushrooms and fungal-yeast flora
There are many fungal cultures, they are separated into their own kingdom of organisms, many processes in them occur according to their own laws.Regarding the human body, fungi are of greatest importance as an integral part of the microbiotic portrait of the intestine.Fungi for the most part belong to the opportunistic flora, which we consider as an element of the total antigenic load that depletes our body and triggers a cascade of many pathological reactions.
Previously, fungal systemic infections were most common in patients with severe immunodeficiencies, including HIV-associated ones.In a healthy organism, clinicians did not see fungal damage worse than fungus on the nails, because the immune system was enough to restrain reproduction at a low level.Today, fungal infections, isolated and as complications of other diseases, are observed very often.Therefore, earlier we discussed an isolated virus or isolated thrush, which could be treated one-time and symptomatically by prescribing antiviral therapy or using a local antifungal suppository that relieved the symptoms of thrush.
Now the situation has changed.Previously, fungi appeared in the body and were considered in classical medicine as a consequence of an immunodeficiency state, which arose, for example, after a long course of antibiotics.In addition to pathogenic microbes, antibiotics also cleared out the rest and positive contingent of microbes.And positive microbes have a fairly powerful immunological effect that supports us.And against the background of this depletion of microbial positive microflora, the fungal flora actively grew.Therefore, pharmacists, when a person bought some strong antibiotics, could also offer him an antifungal drug, for example the same nystatin.
For the first time, I saw the role of fungal infections in diseases of the nervous system in immunodeficient children who were treated with chemotherapy and large doses of antibiotics due to acute leukemia.Then I, still a novice neurologist, first saw brain aspergillosis - fungi that grow in the brain.And they were also the cause of convulsive syndromes.Therefore, antifungal therapy was part of the mandatory protocol for immune support for immunodeficient children whose immunity was suppressed by chemotherapy.
Now we see brain aspergillosis in ordinary children who do not undergo chemotherapy and do not receive any immunosuppressive drugs.What are chemotherapy drugs?This is a powerful mitochondrial toxin that kills foreign cells, not typical foreign cells, but it also affects your own cells, being a mitochondrial poison.Therefore, in children who receive chemotherapy, and in adults who receive chemotherapy, you can notice weakness, weakness, decreased muscle strength, that is, the very condition that we call mitochondrial dysfunction.Only this mitochondrial dysfunction was iatrogenically modulated.People consciously agree to such side effects, hoping that these chemotherapy drugs will help overcome a life-threatening condition, because one can live with mitochondrial dysfunction, but with a progressive cancer process, one can live for a limited time.
Now the mitochondrial status of an ordinary child, alas, is not much higher than the mitochondrial status of a child who received chemotherapy 15 years ago, which is another confirmation of the concept of generational degeneration.
The presence of fungal microflora and fungal damage to the body is a manifestation of immunodeficiency.And normally, an ordinary healthy person should not have it.What we see now is almost total population intestinal candidiasis.Clinically, it actually does not manifest itself at all.But vaginal candidiasis, for example, a more noticeable condition: discomfort, discharge, odor, itching - can no longer go unnoticed.For this reason, women turn to a gynecologist.And now we consider vaginal candidiasis as a local phenomenon of systemic fungal damage with the main focus in the gastrointestinal tract.You can also examine your nails and skin, and often rashes, damage, spots, and depigmentation are also found there, but for some reason they treat this more calmly, considering it as an allergic or some other skin manifestation.It must be said that fungal damage to the mucous membranes can still be diagnosed in the laboratory.
Of course, the results of laboratory examination of smears and tests make it possible to see this.But intestinal candidiasis can only be seen using laboratory tests.Cutaneous candidiasis, easily assessed clinically, does not necessarily begin immediately externally, most often it is a manifestation of a long-term internal process that takes place in the intestines.
In general, it should be noted that there is a significant relationship between fungal damage and the diet that a person follows.Carbohydrates, especially simple ones, are a product ready for consumption by mushrooms, which they process and form substances necessary for their own metabolism, but which are toxic to the human body in general and the nervous system in particular.
Often, gas formation in the abdomen, pain, and bloating are the result of fungal and yeast fermentation in our intestines.During this fermentation, in fact, the intestines work like a moonshine still, as a result of which organic acids are synthesized - caffeic and tartaric, which are not named so by chance.And therefore, the consumption of various syrups, carbonated waters, sweets, fruits, starchy root vegetables - everything that contains carbohydrates, maintains an excellent nutrient medium for the growth of these fungi and accelerates the synthesis of alcohols and sugars by the fungal and yeast flora.
The launch of fermentation processes in the intestines immediately triggers several more vicious circles.Fermentation in the intestines is a local inflammation, local inflammation is the reason for the acceleration of the development of dysbiosis, while intestinal permeability significantly increases.On the other hand, it also produces a fairly large number of toxins, many of which have a neurotropic effect.
And as a result, a child with low immunity, a high fungal load, and increased intestinal permeability, eats a small amount of sweets and walks for several minutes as if in a state of intoxication.It’s just that this “moonshine still” inside him worked.His intoxication system is weakened, and the permeability of the membrane is increased, so toxins, circulating in the blood, enter the brain and make his behavior hyperactive, restless, cause unmotivated laughter or aggression.And mothers who have already encountered these problems know that these symptoms go away after a course of antifungal therapy plus the prescription of sorbents - drugs that reduce the level of intoxication.The child’s behavior then returns to normal.
Other complications of a fungal infection can be skin, allergic manifestations, stomatitis, sinusitis, adenoiditis, that is, the localization of the fungal flora can be any - this is the nasopharynx, oropharynx, gastrointestinal tract, and vagina, and it can also simply circulate in the blood.Diagnosis of these conditions can be carried out depending on the clinical manifestations or by analyzing organic acids, in which we see waste products of the fungal flora; various smears and blood tests for fungi can be done there, and, based on this, the tactics for the duration of antifungal therapy can be chosen.
Depending on the location, both pharmacological and naturopathic drugs can be used, but a single basis is the parallel treatment of dysbiosis and increasing the immune, hormonal and mitochondrial status.
Viral load and its combinations
There is no person who has not encountered viral diseases, at least everyone has encountered ARVI (acute respiratory viral infection) and influenza.Viruses are one of the most common infectious agents that lead to the development of an inflammatory process and damage to various organs.
Viruses are extremely diverse, they are widespread in nature, they can infect any organism, and they have the important and clinically significant ability to change rapidly to improve their ability to survive.There are many types and approaches to the classification of viruses; in general, all viruses are divided into DNA viruses (they are defined by 7 large families) and more numerous RNA viruses (12 families).Taxometric characteristics, their forms, their virulence, pathogenicity and features of integration into human DNA, as well as their possible oncogenicity and role in the development of serious diseases are studied in more detail in a separate section of microbiology - virology.
The virus can interact with the host cell in four types: productive, integrative, abortive and latent infections.Practice shows that virtually every body has a viral load, while the virus is in the so-called latent state, that is, it does not manifest itself clinically.Symptoms of a viral disease appear only when the body's resistance decreases.For example, herpetic rashes are persistent in nature and appear only with an increase in antigenic load, for example, with the addition of respiratory viruses that cause colds, or with a general decrease in the body's resources - with hypovitaminosis, sleep disturbances and emotional stress, leading to a shift in hormonal levels.
Diagnosing viruses has a number of difficulties; there are general tests and local tests.The general response of the body's immune system and the direct presence, as well as the number of viruses in various environments - saliva, blood, feces, etc. are studied. Viruses are not always found in all environments at the same time, that is, there are often situations when, when examining the oral cavity, the virus is detected in saliva, but is not detected in the pharynx and nasopharynx - and vice versa.Laboratory diagnostics in the basic version is aimed at detecting the main viruses that are often found in humans.This is a group of herpes viruses, rhinoviruses, rotoviruses; according to indications, examinations are carried out for hepatitis B and C viruses, human immunodeficiency virus (HIV).Hepatitis B, C and HIV infection are characterized by a certain clinical picture, while for most other viruses the symptoms do not have clear specificity and can change even during an exacerbation, which further complicates the task of their diagnosis and verification.
A typical example can be considered representatives of the herpes virus family, the most studied by virologists.Most often, the herpes virus manifests itself in the form of typical rashes on the skin and mucous membranes, but, in addition, during the infection, other tissues and organs can be damaged, which is how herpetic pneumonia, encephalitis, uveitis, conjunctivitis, etc. develop. Virologists know about 200 types of herpes viruses, while eight are available for clinical laboratory diagnosis, and a maximum of five are used in routine practice.That is, the vast majority of viral agents remain outside laboratory diagnostics, and therefore fall out of the attention of the clinician.Repeated attempts to detail and identify the specific causative virus have not led to any significant changes in treatment tactics, since real antiviral drugs that work precisely have appeared only in the last few years and are effective only against a few viruses (targeted therapy for hepatitis C, antiretroviral drugs, etc.).In all other cases, there is no specific antiviral therapy, and the drugs used have a wide spectrum of action.
The presence of an immunocompromised immunodeficiency state most likely implies the presence of a viral load, which may be one of the components of the total antigenic load along with bacterial, parasitic and fungal invasion.In the chronic course of the disease, the order of infection, that is, what came first - parasitic invasion, decreased immunity and then exacerbation of the viral infection, or vice versa - is insignificant.Antiviral therapy is included in the structure of the complex anti-inflammatory therapy regimen, and the choice of a specific instrument will depend on the severity of clinical manifestations associated with the viral load, its localization and changes in laboratory parameters.
Thus, antigenic unloading, that is, reducing the number of antigens in the body, both food and any pathogenic invasion, is a basic component on the way to increasing the body’s resources, since it reduces the load on the immune system and detoxification systems, and chronic tension of these systems is energy-consuming, leads to their gradual depletion, and therefore to the progression of pathological processes that destroy the body.